Last-minute holiday shoppers and visitors to the Times Square area of New York City can Stand Up To Cancer simply by using a MasterCard. Every time a shopper in Times Square uses their MasterCard at any of the 90 participating businesses through December 31 at midnight, MasterCard Worldwide will donate $1 to Stand Up To Cancer, up to $1.5 million total.

Stand Up To Cancer is an initiative created to accelerate groundbreaking cancer research that will get new therapies to patients quickly and save lives. SU2C’s goal is to bring together the best and the brightest in the cancer community, encouraging collaboration instead of competition. By galvanizing the entertainment industry, SU2C creates awareness and builds broad public support for this effort.

During this period, any time a visitor to Times Square uses their MasterCard to book a hotel room, buy tickets to a Broadway show, dines out, goes holiday shopping, or just simply buys a toothbrush at any of the 90 participating businesses, MasterCard will make a $1 donation per transaction.

The Stand Up To Cancer Times Square PSA is directed by David Fincher and features appearances by Christy Turlington, Tilda Swinton, Tobey Maguire, Susan Sarandon, Morgan Freeman, Mayor Bloomberg, and Lance Armstrong.

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